Journal: Pharmaceutics
Article Title: Effect of Ciprofloxacin-Loaded Niosomes on Escherichia coli and Staphylococcus aureus Biofilm Formation
doi: 10.3390/pharmaceutics14122662
Figure Lengend Snippet: VP-SEM images of E. coli ( A – C ) and E. coli treated with CIP-loaded niosomes ( D – F ). ( A ) Low magnification (2.00K), ECM shows compact and smooth ECM areas (c), as well as spongy and rough areas (c). ( B ) Higher magnification (5.00K) of the ECM spongy area, ECM trabeculae show a globular structure (inset). ( C ) 3D reconstruction of sample surface topography, ECM trabeculae are represented in white and red areas, and the channels that perforate the ECM are represented with color shades from green to blue. ( D ) Low magnification (2.00K), ECM shows both compact and smooth ECM areas (c), both spongy and rough areas. ( E ) Higher magnification (5.00K) of the ECM spongy area, ECM trabeculae show a fine filamentous network structure (inset). ( F ) 3D reconstruction of sample surface topography, ECM trabeculae are represented in white and red areas, and the channels that perforate the ECM are represented with color shades from green to blue. Note that ECM presents more channels than the control, and trabeculae are thinner than the control sample.
Article Snippet: To further quantitatively analyze the effect of niosomes on E. coli ECM ultrastructure, we used the Hitachi Map 3D Software (v.8.2., Digital surf, Besançon, France) particle analysis tool to detect globular structures that characterize the trabecular system of the control sample and observe if any difference exists in the treated sample.
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